For research use only
| Cat No. | ABC-TC443S |
| Product Type | Human Thyroid Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thyroid |
| Product Code | 8305c; 8305-C; 8305C_1 |
8305C human thyroid carcinoma cells from age 67 female show epithelial morphology,adherent growth,harbor p53 codon 273 mutation,useful for thyroid cancer.
8305C is a human anaplastic thyroid carcinoma cell line derived from the primary tumor of a 67-year-old female patient with thyroid cancer. These cells grow adherently in vitro with a spindle-shaped, fibroblast-like morphology and can be continuously passaged. They exhibit aggressive tumorigenic characteristics typical of anaplastic thyroid carcinoma, one of the most undifferentiated and lethal forms of thyroid cancer. 8305C cells express markers indicative of epithelial-to-mesenchymal transition (EMT), including decreased E-cadherin and elevated vimentin levels, reflecting their invasive phenotype. At the molecular level, they harbor mutations in key oncogenes and tumor suppressors such as TP53, which contribute to their high proliferative and metastatic potential. This cell line is widely used to study anaplastic thyroid cancer biology, mechanisms of chemoresistance, and to evaluate novel therapeutic strategies against aggressive thyroid tumors.
| Product Code | 8305c; 8305-C; 8305C_1 |
| Species | Human |
| Cat.No | ABC-TC443S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thyroid |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Thyroid Cancer Cell Lines |
The 8305C cell line is a model for investigating gene mutations involved in thyroid carcinoma, particularly in undifferentiated forms. It is used to examine molecular mechanisms driving malignant transformation and progression. Notably, its association with p53 mutations provides insight into thyroid cancer development, making it a valuable tool for studying cancer genetics and targeted therapy.
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