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ARPE19

Product Name

ARPE19

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Cat.No

ABC-TC158D

Species

Human

Cell Type

Epithelial

Growth Mode

Adherent

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The ARPE19 cell line, derived from a 19-year-old male, is a spontaneously immortalized retinal pigment epithelial (RPE) cell line that closely mimics in vivo RPE properties. Adherent and culturable for over 30 passages, these cells demonstrate morphological polarization and tight junction formation on laminin-coated filters with low serum concentration, resulting in substantial transepithelial resistance. They express RPE-specific markers CRALBP and RPE-65, indicating stable, polarized monolayers. Compared to other RPE lines, ARPE19 has lower transepithelial resistance and RPE gene expression. With a doubling time of 55-65 hours and 48 population doublings, it exhibits elevated gene expression related to chromatin regulation, early eye development, and muscle contraction networks in iPSC-RPE.

 

Why choose ARPE19 from AcceGen?

The ARPE19 cell line exhibits high viability and quality, maintained under optimal conditions with rigorous daily monitoring to ensure the absence of bacterial and fungal contamination. It is maintained in sterile conditions, consistently tested negative for mycoplasma, and its identity is confirmed through STR analysis.

Disease

Normal

Source Organ

Eye

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

ARPE19 cells are extensively employed in biomedical research, notably in ophthalmology, and serve as a valuable tool for in vitro investigations into retinal pigment epithelium physiology. They enable researchers to study various retinal conditions by manipulating pigment levels, making them a versatile model system. These cells are well-suited for transfection studies and can simulate retinal pigment epithelium pigmentation processes. Nonetheless, researchers should exercise caution when utilizing ARPE19 cells to model native RPE cells in retinal disease research due to the presence of both mortal and immortal cell populations within the line.

Growth Conditions

37 ℃, 5% CO2

Product Type

Human Retinal Pigment Epithelium Cell Line

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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