For research use only
| Cat No. | ABC-TC158D |
| Product Type | Human Retinal Pigment Epithelium Cell Line |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Eye |
| Disease | Normal |
| Product Code | ARPE19, ARPE-19 Cells, Human Retinal Pigment Epithelial Cells ARPE19, RPE Cell Line ARPE-19, hRPE ARPE19 |
ARPE-19 retinal pigment epithelial cells immortalized, form tight junctions, express CRALBP/RPE-65, and maintain stable gene expression long-term.
ARPE-19 is a spontaneously immortalized human retinal pigment epithelial (RPE) cell line established from the normal eye of a 19-year-old male donor. These adherent cells retain key morphological and functional features of native RPE, including polarization, tight junction formation, and epithelial monolayer organization when cultured on laminin-coated membranes under low-serum conditions. ARPE-19 expresses hallmark RPE markers such as CRALBP, RPE-65, and cytokeratin 8/18, indicative of its physiological relevance. The cell line secretes growth factors such as VEGF and PEDF and demonstrates phagocytic activity toward photoreceptor outer segments, reflecting functional characteristics of native RPE. Compared to iPSC-derived RPE cells, ARPE-19 shows elevated expression of genes related to chromatin regulation, eye development, and muscle contraction networks. ARPE-19 is non-tumorigenic and exhibits limited senescence, making it a widely accepted in vitro model for studying retinal physiology, oxidative stress, and degenerative retinal diseases.
| Product Code | ARPE19, ARPE-19 Cells, Human Retinal Pigment Epithelial Cells ARPE19, RPE Cell Line ARPE-19, hRPE ARPE19 |
| Species | Human |
| Cat.No | ABC-TC158D |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Eye |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Retinal Pigment Epithelium Cell Line |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
ARPE-19 cells are a widely recognized in vitro model in ophthalmic research, particularly for studying retinal pigment epithelium physiology, ocular drug transport, and retinal disease mechanisms. They are instrumental in modeling age-related macular degeneration (AMD), oxidative stress responses, and RPE-mediated phagocytosis of photoreceptor outer segments. Additionally, ARPE-19 supports transfection and gene expression studies, enabling exploration of pigmentation, retinal metabolism, and barrier function. However, ARPE-19 contains a mixture of mortal and immortal cell populations, and its gene expression profile differs from native RPE cells, therefore, careful experimental validation is advised when modeling retinal pathophysiology or evaluating therapeutic interventions.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
