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Tumor Cell Lines

ATDC5

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Differentiate to chondrocytes, unidentifiable pigment cells. Teratocarcinoma AT805 derived.
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Product Code

ATDC-5

Species

Mouse

Cat.No

ABC-TC5598

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial-like

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Embryo

Storage

Liquid Nitrogen

Product Type

Mouse Embryo Cell Lines

Description

ATDC5
ATDC5 is a murine chondrogenic cell line originally derived from the teratocarcinoma AT805. ATDC5 exhibits epithelial-like morphology and adherent culture properties. In vitro, ATDC5 cells undergo a continuous phenotypic transition that includes stages from mesenchymal condensation to calcification. Bone morphogenetic protein-2 (BMP-2) can stimulate both early and late differentiation of ATDC5 cells, while activation of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor can inhibit this differentiation potential.
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Citation

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Application

  • ATDC5 is a well-established model for studying chondrogenesis, cartilage formation, and skeletal development. It is widely used to explore chondrocyte differentiation and test therapeutic strategies for cartilage-related diseases. This cell line also supports research on signaling pathways and biomaterial interactions relevant to skeletal tissue engineering.

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