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Ba/F3

Product Name

Ba/F3

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Product Code

BA/F3; BaF3; BAF3; Baf3

Cat.No

ABC-TC060S

Species

Mouse- C3H

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Ba/F3 is a pro-B murine cell line originating from the C3H mouse strain, not the BALB/c mouse strain. Its growth relies on the presence of interleukin-3 (IL-3). One distinctive characteristic of Ba/F3 cells is the lack of endogenous expression of the prolactin receptor, making them reliant on cytokine receptor signaling for their survival and growth. This attribute makes them particularly useful in studying the constitutive properties of specific prolactin receptor (PRLR) variants. Ba/F3 cells have a high susceptibility to cell death in the absence of appropriate stimuli and exhibit a growth pattern in suspension.

 

Why choose Ba/F3 from AcceGen?
There are several compelling reasons to choose Ba/F3 from AcceGen. Firstly, AcceGen ensures the high quality and viability of the Ba/F3 cell line, ensuring that you receive cells that are robust and reliable for your experiments. Additionally, the cells are provided in a sterile condition, minimizing the risk of contamination and ensuring the integrity of your research. AcceGen’s professional operators handle the incubation of the cells under optimal and standardized conditions, guaranteeing consistent growth and performance. Lastly, AcceGen implements rigorous quality control measures to ensure that the Ba/F3 cells meet the highest standards of quality, providing you with confidence in the reliability and reproducibility of your results.

Source Organ

Bone Marrow

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

Ba/F3, a widely used cell line for studying cytokine receptors, offers several applications. As a murine hematopoietic cell line, this particular cell line has gained popularity as a system for screening oncogenic variants found in various cancers. It allows researchers to explore downstream oncogenic signaling pathways and assess the response of driver variants to potential therapeutic interventions. Compared to traditional assays involving fibroblasts or epithelial cells, the Ba/F3 system provides advantages such as rapid cellular proliferation and easy transgene expression through electroporation or retro/lentiviral transduction. These features make Ba/F3 a valuable tool for efficient and sensitive investigations in the field of cancer studies.

Growth Conditions

37 ℃, 5% CO2

Product Type

Mouse Lymphocytes Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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