BALB/c Mouse Bone Marrow Mesenchymal Stem Cells

Description

Mouse Bone Marrow Mesenchymal Stem Cells (BM-MSCs) are isolated from the bone marrow of BALB/c mice and are known for their self-renewal capacity and multipotency. Initially heterogeneous in morphology, these mouse mesenchymal stem cells become a uniform population of fibroblast-like, spindle-shaped cells after passaging. Mouse BM-MSCs can differentiate into osteogenic, adipogenic, and chondrogenic lineages under defined induction conditions. They express typical MSC surface markers such as CD44 and CD90, while lacking hematopoietic markers like CD34 and CD45, indicating their mesenchymal origin and low immunogenicity. These characteristics make them a versatile model for tissue engineering, regenerative medicine, immunomodulation, and disease modeling in both in vitro and in vivo studies.

Application

• BALB/c BM-MSCs are widely used in preclinical studies of tissue regeneration, bone repair, and immune-related diseases. They serve as in vitro and in vivo models for immunomodulation, graft-versus-host disease, autoimmune disorders, and cancer stroma interaction. Their syngeneic compatibility with BALB/c mice makes them ideal for transplantation and mechanistic studies in murine models.