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Transfected Stable Cell Lines

BCMA Reporter Cell Line

  • For research use only

Cat No.

ABC-RC007F
Product Type

Reporter Stable Cell Lines
Cell Type

Epithelial
Species

Human
Host Cell

HEK293
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

BCMA, a TNF receptor in B cells, regulates immunity. It's a key target in multiple myeloma drug evaluation.

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  • BCMA Reporter Cell Line
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Home | Transfected Stable Cell Lines | Reporter Stable Cell Lines | BCMA Reporter Cell Line

Description

B-cell maturation antigen (BCMA, CD269, TNFRSF17) is a member of the TNF receptor superfamily. BCMA is expressed in immune organs and mature B lymphocytes. It plays a crucial role in B cell development and autoimmune reactions. Activation of BCMA by its ligands promotes B cell differentiation and proliferation.The ligands of BCMA, BAFF (B-cell activating factor) and APRIL (proliferation-inducing ligand), are produced by macrophages and dendritic cells. BAFF and APRIL exhibit biological activity as soluble homotrimers.In multiple myeloma, BCMA is extensively expressed at high levels on malignant plasma cells. BCMA expression increases with progression from normal cells to active multiple myeloma, making it a promising tumor target. Additionally, γ-secretase can cleave surface BCMA to form a soluble form (sBCMA), which acts as a soluble decoy to resist immune cells. Therefore, combining BCMA-targeted antibodies with γ-secretase inhibitors represents a novel treatment approach.The Hi-Media BCMA Reporter Cell Line is a luciferase reporter gene cell line. Upon binding of BAFF or APRIL to the BCMA receptor, downstream signaling pathways are activated, leading to luciferase expression. Blocking antibodies can interfere with this signaling cascade. Luciferase readouts indicate the effectiveness of the signaling pathway activation, making it suitable for evaluating the in vitro effects of BCMA-related drugs.

Species

Human
Cat.No

ABC-RC007F
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Lines
Host Cell

HEK293

Application

  • For research use only

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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