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| Product Code | Bovine Pulmonary Artery Endothelial Cells; BPAE |
| Species | Bos Taurus |
| Cat.No | ABC-TC0080 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Endothelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Bovine Lung Cell Lines |
The Bovine Pulmonary Artery Endothelial (BPAE) cell line, derived from the main pulmonary artery of a young cow (Bos taurus). These cells exhibit classic endothelial morphology with adherent growth properties, forming confluent monolayers that closely mimic vascular endothelium in vivo. BPAE cells express angiotensin-converting enzyme (ACE) and retain functional endothelial properties, including nitric oxide (NO) production and redox-sensitive signaling. They are non-tumorigenic but susceptible to bovine viral diarrhea virus (BVDV). This cell line is widely employed to investigate endothelial dysfunction under conditions such as oxidative stress (e.g., cigarette smoke, mercury exposure), hyperoxia, and inflammatory responses (e.g., LPS-induced barrier disruption).
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The Bovine Pulmonary Artery Endothelial (BPAE) cell line serves as a valuable tool in cardiovascular research, offering a robust in vitro model to investigate vascular function, endothelial signaling, and pathologies including hypertension, atherosclerosis, and coronary artery disease. Their ability to model angiogenesis, vascular permeability, and nitric oxide (NO)-mediated responses makes them ideal for studying cardiovascular homeostasis and dysfunction. Moreover, BPAE cells are widely used to explore mechanisms underlying diabetes-related cardiovascular complications, as well as endothelial dysfunction induced by environmental pollutants, smoking, oxidative stress, and inflammation. Additionally, they facilitate the development of advanced co-culture models, such as liver-endothelial systems, distinguished by their properties support the expression of liver-specific functions, enabling more physiologically relevant studies in toxicology, pharmacology, and tissue engineering.
