C57BL/6 Mouse Lung Microvascular Endothelial Cells

Description

C57BL/6 mouse lung microvascular endothelial cells are isolated from pathogen-free adult C57BL/6 mice, commonly used in biomedical research. These cells are derived from lung tissue and are vital for maintaining blood-brain barrier function, essential for substance exchange and protecting cardiovascular, metabolic, and pulmonary health. These cells are cryopreserved at early passage. Morphologically, they exhibit a typical endothelial phenotype with cobblestone-like confluence. They express endothelial markers like VE-cadherin, CD31, von Willebrand factor, and AF1002. These cells are used in models of ARDS, pneumonia, and pulmonary edema.

Application

• Mouse model is commonly used to study human disease. Some human diseases, such as hypertension, diabetes, atherosclerosis, and lung injury, share a common mechanism, endothelial dysfunction. The isolation and primary culture of mouse endothelial cells is an effective and valuable tool for investigating the role of endothelial genes in endothelial dysfunction-associated diseases. C57BL/6 mouse primary lung microvascular endothelial cells are widely used in studying vascular tube formation, cell adhesion and migration, and transendothelial resistance in vascular research.