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Transfected Stable Cell Lines

CALCRL RAMP1 Reporter HEK-293 Cell Line

  • For research use only

Cat No.

ABC-RC011F
Product Type

Reporter Stable Cell Lines
Cell Type

Epithelial
Species

Human
Host Cell

HEK293
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

CALCRL RAMP1 Reporter HEK-293 Cell Line ,HEK293 reporter line with RAMP1/CRCP for CGRP receptor signaling, ideal for drug screening and pathway studies.

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  • CALCRL RAMP1 Reporter HEK-293 Cell Line
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Home | Transfected Stable Cell Lines | Reporter Stable Cell Lines | CALCRL RAMP1 Reporter HEK-293 Cell Line

Description

The calcitonin gene-related peptide (CGRP) family includes calcitonin, amylin, CGRP, and adrenomedullin. Among them, human α-CGRP and β-CGRP proteins differ by three amino acids.Receptors of the CGRP family consist of two subtypes: calcitonin receptors (CALCR, CTR) binding to CT, and calcitonin receptor-like receptor (CRLR, CLR, CALCRL). The CGRP receptor comprises calcitonin receptor-like receptor, receptor activity-modifying protein (RAMP1), and CGRP receptor component protein (CRCP). RAMP1 is essential for transporting the CGRP receptor to the membrane and coupling with CGRP agonists. CRCP is involved in the interaction between the CGRP receptor and G protein. Upon ligand binding, the complex interacts with the G protein, leading to adenylate cyclase activation, cAMP production, and the stimulation of cAMP-dependent signaling pathways, ultimately inducing gene expression.Preclinical evidence suggests that during migraines, sensory neurons activated in the trigeminal ganglion release CGRP from nerve terminals in the meninges. Released CGRP binds and activates the CGRP receptor, causing vasodilation and plasma extravasation. Therefore, CGRP antagonists are becoming prominent in migraine treatment.CALCRL RAMP1 Reporter Cell Line is a luciferase reporter cell line based on the cAMP signaling pathway. When CGRP binds to CALCRL/RAMP1, it activates the expression of luciferase by stimulating the cAMP signaling pathway. Luciferase readings reflect the activation effect of the signaling pathway, making it suitable for evaluating the in vitro effects of CGRP-related drugs.

Species

Human
Cat.No

ABC-RC011F
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Lines
Host Cell

HEK293

Application

  • For research use only

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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