Canine Bone Marrow Dendritic Cells

Description

Canine Bone Marrow Dendritic Cells are primary immune cells isolated from the femurs and tibias of healthy beagle dogs (Canis lupus familiaris). These cells exhibit typical dendritic morphology with extended processes and display strong antigen-presenting capabilities. They are derived from hematopoietic progenitors and differentiated upon stimulation by GM-CSF or Flt3L. They express key surface markers such as CD11c, MHC class II, CD80, and CD86, confirming their immunostimulatory phenotype. LPS stimulation induces MHC-II and co-stimulatory molecule expression. As critical regulators of the innate and adaptive immune response, canine dendritic cells (DCs) are essential for initiating T cell-mediated immunity and maintaining immune surveillance. These cells are particularly relevant in translational immunology, vaccine development, and comparative oncology studies.

Application

• Canine Bone Marrow Dendritic Cells are used in canine immunology research, cancer immunotherapy studies, and vaccine design. These cells support investigations into antigen presentation, T cell activation, and immune checkpoint regulation. They serve as valuable tools in developing dendritic cell-based vaccines for cancer, infectious diseases, and autoimmune conditions in both veterinary and comparative biomedical research.