Canine Bone Marrow Dendritic Cells are primary immune cells isolated from the femurs and tibias of healthy male and female beagle dogs. In vitro, they are non-adherent and short-lived. They are derived from hematopoietic progenitors and differentiated using GM-CSF or Flt3L. Cells express CD4, CD8, CD1c, CD11b, CD11c, and CD14, detected by flow cytometry or immunofluorescence. LPS stimulation induces MHC-II and co-stimulatory molecule expression. Karyotype analysis has not been reported. They are non-tumorigenic and non-metastatic, free of Mycoplasma, bacteria, fungi, yeast, and tested negative for canine-specific viruses like CDV and CAV. These cells are ideal for veterinary immunology and translational antigen-presentation studies under BSL-2 conditions.
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