For research use only
| Cat No. | ABC-TC0172 |
| Product Type | Human Melanoma Cell Lines |
| Cell Type | Fibroblast |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Cutaneous Melanoma |
| Product Code | COLO-800, Human Melanoma Cell Line COLO-800, COLO 800, COLO800, COLO-0800, Human Skin Cancer Cells, Melanoma Study Cells |
Study COLO-800, a melanoma cell line from a teen patient, showing epithelial traits, melanin production, and mutations impacting cell growth.
COLO-800 is a human melanoma cell line derived from a subcutaneous tumor of a 14-year-old male patient. The cells exhibit fibroblast-like morphology and grow adherently in culture, representing characteristic COLO-800 cell morphology. A defining feature of this cell line is its ability to produce melanin, a property commonly associated with malignant melanoma. COLO-800 maintains microsatellite stability (MSS) and a hypotriploid karyotype with complex chromosomal rearrangements typical of aggressive melanoma. Notably, these cells harbor the BRAF V600E mutation, identified through genetic characterization and COLO-800 DNA sequencing analyses. They express melanoma-associated markers including S100, HMB-45, and Melan-A, along with epithelial markers EpCAM and vimentin, defining a set of well-established COLO-800 biomarkers. Melanin production in these cells contributes to oxidative stress and DNA damage, further influencing malignant progression. These genetic and phenotypic features drive dysregulation of oncogenic signaling pathways such as the MAPK/ERK cascade, promoting proliferation, dedifferentiation, and immortalization. Consistent with these properties, COLO-800 exhibits pronounced COLO-800 metastatic potential and strong tumorigenicity in xenograft models, making it a valuable in vitro and in vivo model for melanoma biology, therapeutic evaluation, and metastasis research.
| Product Code | COLO-800, Human Melanoma Cell Line COLO-800, COLO 800, COLO800, COLO-0800, Human Skin Cancer Cells, Melanoma Study Cells |
| Species | Human |
| Cat.No | ABC-TC0172 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Cutaneous Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
The COLO-800 cell line is used as a tumor model to simulate melanoma, making it critical for understanding the molecular mechanisms underlying melanoma tumorigenicity and treatment resistance. Research on the genetic pathways of this cell line may help identify genes related to melanoma development and provide a theoretical basis for diagnosing and treating hereditary melanoma.
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