1
Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
| Product Code | COLO 800; COLO #800; COLO800; Colorado 800 |
| Species | Human |
| Cat.No | ABC-TC0172 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Cutaneous Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
COLO-800 is a human cutaneous melanoma cell line that was originally isolated from a subcutaneous nodule of a 14-year-old male patient with melanoma. COLO-800 exhibits mainly epithelial-like morphology with few look like fibroblasts or neurons and adherent culture properties. A basic characteristic of these cells is the ability to produce melanin. The pro-oxidative effect of melanin leads to increased levels of oxygen free radicals within the cells, which in turn damages the DNA of melanocytes. These mutations result in the overactivation of various cell signaling pathways, such as the MAPK pathway, leading to uncontrolled proliferation, dedifferentiation, and immortalization of specific cell types.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
The COLO-800 cell line is used as a tumor model to simulate melanoma, making it critical for understanding the molecular mechanisms underlying melanoma tumorigenicity and treatment resistance. Research on the genetic pathways of this cell line may help identify genes related to melanoma development and provide a theoretical basis for diagnosing and treating hereditary melanoma.
