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| Product Code | COV-434; COV 434 |
| Species | Human |
| Cat.No | ABC-TC0191 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Ovary |
| Disease | Ovarian Small Cell Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Ovarian Cancer Cell Lines |
The COV434 cell line is a human ovarian cancer cell line established from a solid primary ovarian tumor in a 26- to 27-year-old female patient. COV434 cells show epithelial-like morphology, polygonal shape, and adherent growth in DMEM with 10% FBS at 37°C, 5% CO₂. They possess a near-diploid karyotype with low chromosomal complexity and show loss of SMARCA4 and SMARCA2, while SMARCB1/INI1 remains intact. These cells express FSH receptor, aromatase, AE1/AE3, and Toll-like receptors but lack LH receptor. They constitutively secrete IL-8, supporting immune-oncology research. In vivo, COV434 is tumorigenic, forming tumors with elevated serum calcium—a hallmark of SCCOHT—though migratory and invasive potential is limited.
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The COV434 cell line has multiple important applications in ovarian research. Firstly, it can serve as an in vitro model to assess therapeutic interventions on the growth and survival of ovarian cancer cells. Researchers can use COV434 cells to evaluate anti-proliferative treatment efficacy. Additionally, studying COV434 cells enables the investigation of signaling pathways associated with ovarian cancer cell proliferation, potentially uncovering new therapeutic targets. Furthermore, COV434 cells express Toll-like receptors (TLRs) and constitutively secrete IL-8, supporting their use in immunological studies. Their ability to mount an inflammatory response at the transcriptional level upon exposure to pathogen-associated molecular patterns (PAMPs) highlights their potential as the valuable material for studying immune responses.
