Cynomolgus Monkey Hepatocytes

Description

Cynomolgus Monkey Hepatocytes are primary hepatocytes isolated from the liver of Macaca fascicularis and cryopreserved post–primary culture, and are frequently referenced in comparative primate liver studies under terms such as cynomolgus monkey hepatocytes, with broader tissue context often described simply as monkey liver in pharmacokinetic and metabolic research. These polygonal epithelial cells retain essential hepatic functions, including xenobiotic metabolism, urea synthesis, glycogen storage, and lipid regulation. They express hepatocyte-specific markers such as albumin, α1-antitrypsin, and cytochrome P450 enzymes (e.g., CYP3A4, CYP1A2), reflecting active phase I/II metabolic pathways. Cultured in suspension, they offer a physiologically relevant model for evaluating drug metabolism, hepatotoxicity, and liver disease mechanisms. Due to their metabolic and genomic similarity to human hepatocytes, Cynomolgus hepatocytes are extensively used in preclinical pharmacokinetics and safety assessment. Repeated freeze-thaw cycles should be avoided to maintain viability and enzymatic activity.