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Tumor Cell Lines

Daudi

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The Daudi line was derived from a 16-year-old Black male with Burkitt's lymphoma by E. Klein and G. Klein in May, 1967. The cells are negative for beta-2-microglobulin. They are positive for EBNA, VCA and Surface immunoglobulin (sIg+).
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Product Code

DAUDI; NK-10A; NK-10a; NK 10a; NK10a; N

Species

Human

Cat.No

ABC-TC0204

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Lymphoblast

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Blood

Disease

Burkitt’s Lymphoma

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Lymphoma Cell Lines

Description

Daudi
Daudi is a human Burkitt’s lymphoma B lymphoblast cell line that was originally derived from the peripheral blood of a 16-year-old African male patient diagnosed with Burkitt’s lymphoma in 1967. Daudi cells exhibit typical lymphoblast-like morphology and suspension culture properties. The stemline karyotype number of Daudi is 46, consistent with a stable diploid chromosomal composition. This cell line expresses mRNA of the proto-oncogene BCL2, which plays a critical role in apoptosis regulation. Daudi is tumorigenic in nude mice.
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Citation

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Application

  • These well-characterized Daudi B lymphoblasts have been extensively used in the study of leukemogenesis, acting as a reliable in vitro model for understanding the intricacies of B cell biology. Their utility extends to the analysis of B cell surface antigens, supporting studies on antigen expression and characterization. In addition, Daudi cells are employed in the testing of cytotoxic drugs, mutational analysis, and investigations into apoptotic mechanisms, providing valuable insights for research across these pivotal areas in oncology and immunology.

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