DH82

Description

DH82 was originally established from a ten-year-old male Golden Retriever with malignant histiocytosis. DH82 exhibits macrophage-like morphology and semi-adherent culture properties (i.e., some cells grow in suspension). DH-82 are capable of phagocytizing latex particles to eliminate foreign substances. DH82 expresses an Fc gamma receptor on the cell surface , thus promoting the phagocytosis of antibody-coated pathogens or particles. In addition, these cells do not express Fc mu and C3b receptors, and they do not produce IL-1, which binds complement proteins during immune responses, offering a controlled environment for investigating specific immune mechanisms potentially affected by these receptors.

Application

• The DH82 cell line offers a versatile platform for diverse biological investigations. With its macrophage-like morphology, potent phagocytic capability, and unique receptor expression profiles, it serves as an invaluable model for delving into immune responses, cellular cytotoxicity, and cytokine-related studies. DH82 cells prove particularly advantageous for probing immune responses, antibody-dependent cellular cytotoxicity (ADCC), and related research domains. Notably, the absence of key receptors, such as Fc mu and C3b, creates a controlled context to unravel precise immune mechanisms influenced by these receptors. Additionally, the cell line finds application in comprehending the impact of IL-1 on various biological processes and uncovering the intricacies of IL-1-mediated diseases.