For research use only
| Cat No. | ABC-TC0209 |
| Product Type | Canine Macrophage Cell Lines |
| Cell Type | Macrophage |
| Species | Canis Familiaris |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | DH-82; DH 82 |
DH82, from a Golden Retriever with histiocytosis, shows macrophage morphology, phagocytizes particles, expresses Fc gamma receptor, no IL-1.
DH82 cell line, derived from a 10-year-old male Golden Retriever with malignant histiocytosis, serving as a valuable model for studying monocyte/macrophage biology and immune responses. These cells exhibit macrophage-like morphology and semi-adherent growth, with some cells in suspension. These cells are phagocytic, capable of ingesting latex particles and antibody-coated pathogens via Fc gamma receptors (FcγR), but lack Fc mu (IgM) and C3b receptors, limiting complement-mediated uptake. Unlike primary macrophages, DH82 cells do not produce IL-1, reducing confounding inflammatory signals in immune studies. Its tumorigenicity has been confirmed in xenograft models forming subcutaneous lesions in immunodeficient mice following implantation. Their unique receptor profile makes them ideal for investigating antibody-dependent phagocytosis without interference from complement or IgM pathways. DH82 is widely used in canine immunology research, particularly for studying histiocytic diseases, vaccine responses, and macrophage function.
| Product Code | DH-82; DH 82 |
| Species | Canis Familiaris |
| Cat.No | ABC-TC0209 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Macrophage |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Canine Macrophage Cell Lines |
DH82 cells are widely used as an in vitro model for canine histiocytic sarcoma and immunological research, including studies of macrophage function, receptor‑mediated phagocytosis, and Fc‑gamma receptor biology. They also serve as a host cell model for studying Ehrlichia canis infection and canine tick‑borne disease pathogenesis. In addition, specific applications include studying intracellular pathogen mechanisms (e.g., Leishmania infection), assessing nanoparticle uptake and toxicity, and modeling inflammatory responses through cytokine profiling. Moreover, DH82 cells are used in toxicology studies to examine the effects of environmental toxins on immune cell function.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
