Dunkin Hartley Guinea Pig Peripheral Blood Mononuclear Cells

Description

Dunkin Hartley Guinea Pig Peripheral Blood Mononuclear Cells (PBMCs) are isolated from healthy guinea pigs of the standardized Dunkin Hartley strain, a preferred model for infectious disease and immunology research. They consist of lymphocytes (T cells, B cells, NK cells) and monocytes that form the basis of immune responses in this important preclinical model. They maintain native morphology and functionality, expressing conserved immune markers including CD4, CD8, and MHC class II molecules. The cells demonstrate robust proliferative responses to mitogens and antigens, making them particularly valuable for tuberculosis research (M. tuberculosis infection models) and allergic disease studies due to guinea pigs’ human-like immune responses. Characteristic gene expression profiles include IL-2, IFN-γ, and species-specific cytokine receptors. These Dunkin hartley guinea pigs-derived PBMCs offer a reliable platform for comparative immunology studies and for evaluating novel vaccines or immunotherapies in a model with translational relevance to human immune responses.