For research use only
| Cat No. | ABC-TC0246 |
| Product Type | Human Esophageal Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Oesophagus |
| Disease | Esophageal Adenocarinoma |
| Product Code | ESO51 |
ESO51 oesophageal adenocarcinoma cells enable cancer research, drug testing, and molecular profiling from Barrett’s mucosa-associated adenocarcinoma.
ESO51 is a human gastric signet ring cell carcinoma cell line derived from distal oesophagus of a 74-year-old male with advanced gastric adenocarcinoma. This cell line consists of polymorphic cells that grow in clusters in suspension. The cells have a human flat bimodal hyperdiploid/hypertetraploid karyotype with chromosome numbers ranging from 51-63 (hyperdiploid) and 90-121 (hypertetraploid). They harbor a TP53 mutation and express epithelial and mesenchymal markers, including cytokeratin-7, cytokeratin-8, cytokeratin-18, cytokeratin-19, EpCAM, and vimentin. ESO51 is tumorigenic with limited observed metastasis in standard models. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | ESO51 |
| Species | Human |
| Cat.No | ABC-TC0246 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Oesophagus |
| Disease | Esophageal Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Esophageal Cancer Cell Lines |
ESO51 cells serve as a critical in vitro model for studying the pathogenesis and therapeutic interventions for this malignancy. Its primary applications include drug screening and efficacy testing in oncology platforms to evaluate novel chemotherapeutic agents. It is used for genetic and molecular profiling, and mutation analysis of drivers like TP53 to elucidate disease mechanisms and identify therapeutic vulnerabilities. This authenticated, tumorigenic model is further validated for translational research in esophageal adenocarcinoma biology, including metastasis studies and biomarker discovery.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
