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| Product Code | H441; H-441; NCI-H441-4; NCI-441; NCIH441 |
| Species | Human |
| Cat.No | ABC-TC525S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Papillary Adenocarinoma |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
H441 (NCI-H441) is a human lung papillary adenocarcinoma cell line that was originally isolated in 1982 from the pleural effusion of a male patient with papillary adenocarcinoma of the lung. H441 exhibits epithelial-like morphology and primarily grows as an adherent monolayer. This cell line is hyperdiploid, with a modal chromosome number of 52, though variations from 44 to 59 chromosomes. H441 harbors a KRAS mutation (p.G12V; c.35G>T).
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The H441 cell line serves as a versatile tool in multiple research fields. In the study of human lung adenocarcinoma, it helps elucidate alterations in intermediate filament protein expression. As a type II pneumocyte cell line in alveolar models, it enables the examination of oxidative stress and pro-inflammatory responses triggered by heated tobacco products. Moreover, it is widely used in transfection experiments to express pulmonary surfactant protein SP-B, contributing to a better understanding of pulmonary physiology and disease.
