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HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN1 L286V)

  • For research use only

Cat No.

ABC-SC0060T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Alzheimer’s Disease
Storage

Liquid Nitrogen

HighQC™ iPSC-Derived Neural Stem Cells (PSEN1 L286V) model Alzheimer’s pathology with a familial mutation background, ideal for CNS drug discovery.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN1 L286V)
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN1 L286V)

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-Alzheimer's Disease Patient (PSEN1 L286V) are generated from induced pluripotent stem cells (iPSCs) derived from a patient carrying the PSEN1 L286V mutation. They express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin, and spontaneously form polarized neural rosette structures when seeded as monolayers. They provide a valuable model for investigating alterations in γ-secretase activity, dysregulated APP processing, and downstream tau pathology. These PSEN1 L286V iPSC-derived NSCs are suitable for drug screening, CRISPR gene editing, and mechanistic studies related to early-onset familial Alzheimer's disease. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN1 L286V), hIPSC-NSC-AD-PSEN1-L286V, Human IPSC Neural Stem Cells Alzheimer PSEN1 L286V
Species

Human
Cat.No

ABC-SC0060T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Alzheimer’s Disease
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • This iPSC-derived neural stem cell line from an Alzheimer’s disease patient with the PSEN1 L286V mutation provides a reliable human in vitro model to investigate familial Alzheimer’s mechanisms. It supports studies of amyloid precursor protein processing, γ-secretase dysfunction, and neurodegenerative pathways, making it valuable for drug screening and disease-modifying strategy development in neurodegenerative disorders.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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