HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN1 M146L)

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-Alzheimer's Disease Patient (PSEN1 M146L) are generated by reprogramming patient somatic cells followed by directed neural differentiation. These cells express typical markers of cortical neural stem and progenitor cells, including PAX6, FOXG1, and Nestin, and can form polarized neural rosette structures upon induction under defined monolayer culture conditions. They retain self-renewal and multipotency in vitro. The PSEN1 M146L mutation is known to alter γ-secretase activity and accelerate amyloid-beta production, making this model highly suitable for studying early-onset familial Alzheimer's disease. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.