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HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN2 N141I)

  • For research use only

Cat No.

ABC-SC0063T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Alzheimer’s Disease
Storage

Liquid Nitrogen

HighQC™ Human IPSC-Derived Neural Stem Cell (Alzheimer’s, PSEN2 N141I) supports neurodegeneration modeling, PSEN2 mutation analysis, and AD drug testing.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN2 N141I)
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN2 N141I)

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-Alzheimer's Disease Patient (PSEN2 N141I) are derived from a patient with familial Alzheimer's disease. These cells express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin, and are capable of differentiating into neurons and glial cells. The PSEN2 N141I mutation is associated with altered γ-secretase processing and early neuronal degeneration. These PSEN2 N141I iPSC-derived NSCs provide a valuable platform for investigating PSEN2-related pathogenic mechanisms and for studying gene–environment interactions in Alzheimer's disease development under in vitro controlled conditions. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (PSEN2 N141I), hIPSC-NSC-AD-PSEN2-N141I, Human IPSC Neural Stem Cells Alzheimer PSEN2 N141I
Species

Human
Cat.No

ABC-SC0063T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Alzheimer’s Disease
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • Derived from iPSCs with the PSEN2 N141I mutation, these neural stem cells enable investigation of PSEN2-mediated neurodegenerative mechanisms in Alzheimer’s disease. Researchers can examine endoplasmic reticulum stress, amyloid-beta generation, and mitochondrial defects using this disease-specific neural model, supporting both fundamental studies and drug discovery pipelines. Their unique genetic background makes them particularly valuable for exploring the distinct roles of PSEN2 mutations in early-onset Alzheimer’s pathogenesis.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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