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HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HOM

Product Name

HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HOM

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Cat.No

ABC-SC0067T

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human Human IPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.

The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson’s disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson’s disease patients (West et al., 2005).

Source Organ

Human Stem Cell Collection

Citation Guide

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Product Type

Human Induced Pluripotent Stem Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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