HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HOM

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-LRRK2 G2019S HOM are a neural stem cell line derived from human iPSCs with a homozygous G2019S mutation introduced into the LRRK2 gene using CRISPR-Cas9 gene editing. Both alleles carry the G2019S mutation. These neural stem cells express typical markers of neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin. The LRRK2 G2019S mutation is the most common pathogenic variant in both familial and sporadic Parkinson's disease and is associated with abnormal autophagy, mitochondrial dysfunction, and dopaminergic neuronal vulnerability. These LRRK2 G2019S homozygous iPSC-derived NSCs are valuable for investigating early disease mechanisms that manifest at the neuron stage and for drug screening under mutation- and stage-specific conditions. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.