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Stem Cells

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT V337M HOM

  • For research use only

Cat No.

ABC-SC0071T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT V337M HOM models tauopathy for neurodegeneration research, edited by CRISPR and homozygous for V337M.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell MAPT V337M HOM
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell MAPT V337M HOM

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-MAPT V337M HOM are a human iPSC-derived neural stem cell line with a homozygous V337M mutation (GTG>ATG) introduced into the MAPT gene using CRISPR-Cas9 gene editing. Both alleles carry the V337M mutation. These neural stem cells express typical markers of cortical neural stem and progenitor cells, including PAX6, FOXG1, and Nestin. This NSC line supports research into tau-related synaptic deficits, cellular stress responses, and high-throughput drug screening targeting tauopathies. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT V337M HOM, hIPSC-NSC-MAPT-V337M-HOM, Human IPSC Neural Stem Cells MAPT V337M Homozygous
Species

Human
Cat.No

ABC-SC0071T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • These MAPT V337M homozygous iPSC-Derived NSCs allow precise exploration of familial frontotemporal dementia mechanisms. It is useful for studying tau aggregation, synaptic dysfunction, and neuronal cell death in a human context. Ideal for evaluating therapeutic strategies aimed at reducing mutant tau toxicity. Its ability to mirror the genetic basis of familial cases enhances the relevance of preclinical findings to clinical scenarios.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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