HighQC™ Human IPSC From B-Lymphocyte-Ceroid Lipofuscinosis(Neuronal 2-Late Infantile Type)

Description

HighQC™ Human IPSC From B-Lymphocyte-Ceroid Lipofuscinosis (Neuronal 2-Late Infantile Type) is a disease-specific induced pluripotent stem cell line generated from B-lymphocytes isolated from the peripheral blood mononuclear cells (PBMCs) of a donor diagnosed with Neuronal Ceroid Lipofuscinosis Type 2 (CLN2), a rare neurodegenerative lysosomal storage disorder. The resulting CLN2 disease iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. They preserve pluripotency and show CLN2-related cellular traits. These cells maintain the fundamental capacity for trilineage differentiation into ectoderm, mesoderm, and endoderm derivatives. Core pluripotency marker SSEA-4 is expressed. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.