HighQC™ Human IPSC From Fibroblast-Charcot-Marie-Tooth Syndrome

Description

HighQC™ Human IPSC From Fibroblast-Charcot-Marie-Tooth Syndrome is a disease-specific human induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with Charcot-Marie-Tooth (CMT) disease, a genetically heterogeneous group of inherited peripheral neuropathies. The reprogramming was performed using non-integrating episomal plasmid method. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with well-defined borders and a high nucleus-to-cytoplasm ratio. These human iPSC cell lines maintain pluripotency for CMT-related neural mechanism studies. These cells maintain the fundamental capacity for trilineage differentiation into cell types representing all three germ layers (ectoderm, mesoderm, and endoderm). They express the core pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.