HighQC™ Human IPSC From Fibroblast-Huntington Disease

Description

HighQC™ Human IPSC From Fibroblast-Huntington Disease is a disease-specific human induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with Huntington’s Disease (HD), an autosomal dominant neurodegenerative disorder caused by a Cytosine-Adenine-Guanine (CAG) trinucleotide repeat expansion in the Huntingtin (HTT) gene. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. The cells maintain pluripotency and model HD-related physiological traits. They retain the fundamental capacity for trilineage differentiation into cell types of the ectoderm, mesoderm, and endoderm germ layers. These iPSCs express the core pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.