HighQC™ Human IPSC From Fibroblast-Hutchinson-Gilford Progeria Syndrome

Description

HighQC™ Human IPSC From Fibroblast-Hutchinson-Gilford Progeria Syndrome is a disease-specific human induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder characterized by accelerated aging caused by mutations in the LMNA gene. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. They maintain pluripotency and reflect HGPS aging-related traits. These cells retain the fundamental capacity for trilineage differentiation into cell types of the ectoderm, mesoderm, and endoderm germ layers. They express the core pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.