HighQC™ Human IPSC From Fibroblast-Long QT Syndrome 2

Description

HighQC™ Human IPSC From Fibroblast-Long QT Syndrome 2 is a disease-specific induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with Long QT Syndrome Type 2 (LQT2), a cardiac channelopathy caused by mutations in the KCNH2 gene. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with well-defined borders and a high nucleus-to-cytoplasm ratio. These cells maintain the fundamental capacity for trilineage differentiation into ectoderm, mesoderm, and endoderm derivatives. They harbor LQT2-related channel characteristics, recapitulate cardiac electrophysiological function, and express the core pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.