HighQC™ Human IPSC From Fibroblast-Miller-Dieker Lissencephaly Syndrome

Application

• HighQC™ Human iPSCs From Fibroblasts-Miller-Dieker Lissencephaly Syndrome (Miller-Dieker Syndrome iPSCs, Lissencephaly syndrome iPSC model, Human MDS patient-derived iPSCs) provide a valuable in vitro model for investigating chromosome abnormality–associated neurodevelopmental processes, particularly those involved in cortical development and neuronal migration. These cells support studies on gene dosage effects, chromatin regulation, and developmental signaling pathways underlying lissencephaly-related phenotypes. In addition, they are well suited for directed neural differentiation, disease modeling, and comparative transcriptomic analyses, enabling mechanistic research on how large-scale genomic alterations impact early human brain development under controlled experimental conditions.