HighQC™ Human IPSC From Fibroblast-Monocarboxylate Transporter 8-Specific Thyroid Hormone Cell Transporter Deficiency

Description

HighQC™ Human IPSC From Fibroblast-Monocarboxylate Transporter 8-Specific Thyroid Hormone Cell Transporter Deficiency is a disease-specific human induced pluripotent stem cell (iPSC) line derived from dermal fibroblasts of a donor diagnosed with Allan-Herndon-Dudley syndrome, an X-linked disorder caused by mutations in the SLC16A2 gene encoding the Monocarboxylate Transporter 8 (MCT8). The reprogramming was performed using a non-integrating episomal plasmid method. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. These MCT8 deficiency iPSCs sustain pluripotency for thyroid hormone transport mechanism studies. They retain the fundamental capacity to differentiate into cell types of all three germ layers (ectoderm, mesoderm, and endoderm) under directed conditions. Core pluripotency marker SSEA-4 is expressed. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.