HighQC™ Human IPSC From Fibroblast-Pitt-Hopkins Syndrome

Description

HighQC™ Human IPSC From Fibroblast-Pitt-Hopkins Syndrome is a disease-specific human induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with Pitt-Hopkins Syndrome (PTHS), a rare neurodevelopmental disorder caused by haploinsufficiency of the TCF4 gene. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. They sustain pluripotency and show PTHS-related developmental traits. These cells retain the fundamental capacity for trilineage differentiation into cell types of the ectoderm, mesoderm, and endoderm germ layers. They express the core pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.