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HighQC™ Human IPSC From Fibroblast-Vici Syndrome

  • For research use only

Cat No.

ABC-SC2035
Product Type

Human iPSCs
Cell Type

Induced Pluripotent Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Fibroblast
Disease

Vici Syndrome
Storage

Liquid Nitrogen

HighQC™ Human IPSC From Fibroblast-Vici Syndrome offers an iPSC model for autophagy, neurodevelopment, and disease mechanism studies. In vitro models.

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  • HighQC™ Human IPSC From Fibroblast-Vici Syndrome
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced Pluripotent Stem Cells (iPSCs) | HighQC™ Human IPSC From Fibroblast-Vici Syndrome

Description

HighQC™ Human IPSCs From Fibroblasts-Vici Syndrome are generated from human skin fibroblasts obtained from an individual affected by Vici syndrome, a rare heritable disorder associated with mutations in the EPG5 gene, which plays a critical role in autophagy regulation. These cells display tight colony boundaries, high nuclear-to-cytoplasmic ratios, and clonal growth patterns. Reprogramming was performed using a non-integrating approach, which transiently expresses key human transcription factors to initiate the reprogramming process. These iPSCs exhibit pluripotency, with the ability to differentiate into all three germ layers under defined conditions, and express the pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

HighQC™ Human IPSC From Fibroblast-Vici Syndrome, HighQC™ hiPSC Vici, hiPSC-Vici, HighQC™ Human Induced Pluripotent Stem Cells From Fibroblast-Vici Syndrome
Species

Human
Cat.No

ABC-SC2035
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Induced Pluripotent Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Fibroblast
Disease

Vici Syndrome
Storage

Liquid Nitrogen
Product Type

Human iPSCs
Gene Info

EPG5

Application

  • HighQC™ Human IPSCs From Fibroblasts-Vici Syndrome, also known as Vici Syndrome iPSCs and EPG5 mutation iPSC line, provide a disease-relevant in vitro system for investigating autophagy regulation, intracellular trafficking, and EPG5-dependent cellular pathways, serving as an autophagy-deficient disease model. These cells support mechanistic studies of neurodevelopmental processes, muscle and immune cell differentiation, and cellular stress responses associated with impaired autophagic flux. In addition, they are well suited for directed lineage differentiation, gene function analysis, and comparative molecular profiling, enabling detailed exploration of how EPG5 dysfunction impacts cellular homeostasis under controlled experimental conditions.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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