HighQC™ Human IPSC From PBMC-Primary Lateral Sclerosis

Description

HighQC™ Human IPSC From PBMC-Primary Lateral Sclerosis is a disease-specific human induced pluripotent stem cell (iPSC) line derived from peripheral blood mononuclear cells (PBMCs) of a donor diagnosed with Primary Lateral Sclerosis (PLS). The reprogramming was performed using non-integrating episomal plasmid method. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio and well-defined borders. The cells sustain pluripotency for PLS-related neural pathway mechanism studies. They retain the fundamental capacity for trilineage differentiation into cell types of all three germ layers (ectoderm, mesoderm, and endoderm). Core pluripotency marker SSEA-4 is expressed. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.