HighQC™ Human Mobilized Peripheral Blood Mononuclear Cells

Description

HighQC™ Human Mobilized Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of healthy donors after mobilization with cytokines (such as G-CSF). They mainly include lymphocytes (T/B/NK cells) and monocytest. As the core carrier of innate and adaptive immunity, T cells in PBMCs mediate cellular immunity, B cells produce antibodies, NK cells perform killing functions, and monocytes can differentiate into macrophages/dendritic cells to participate in antigen presentation. The dysfunction of these cells is associated with a variety of diseases: HIV infection leads to CD4+ T cell exhaustion and clonal lymphocyte proliferation in leukemia.

Application

• HighQC™ Human Mobilized Peripheral Blood Mononuclear Cells can be used for in vitro functional evaluation of cell therapies such as CAR-T and TCR-T, as well as pharmacodynamic studies of checkpoint inhibitors (such as PD-1/PD-L1 antibodies). These cells can also be used to evaluate vaccine-induced T/B cell immune responses, including antigen-specific proliferation, cytokine secretion, and antibody production capacity.