HighQC™ Porcine Bone Marrow Mesenchymal Stem Cell

Description

HighQC™ Porcine Bone Marrow Mesenchymal Stem Cells (pBM-MSCs) are primary mesenchymal stem cells isolated from the tibias and femurs of healthy female pigs via density-gradient centrifugation. These cells are derived from normal bone marrow. They are plastic-adherent and display a fibroblast-like, spindle-shaped morphology in vitro. pBM-MSCs are typically used at low passage numbers (<P5) to maintain multipotency. They express classical MSC markers such as wCD44 and CD90, but lack expression of the hematopoietic marker CD45. Immunohistochemistry confirms their differentiation capacity into osteogenic and adipogenic lineages. Calcium-binding proteins are upregulated during osteogenesis. Karyotype analysis has not been reported, and no viral contamination (e.g., PRRSV, PCV2) has been detected. These cells are non-tumorigenic and are commonly used in regenerative medicine, veterinary orthopedics, and stem cell therapy models involving bone and fat tissue repair.

Application

• HighQC™ Porcine Bone Marrow Mesenchymal Stem Cells serve as a key model for studying bone tissue engineering. These cells enable investigation of the osteogenic differentiation potential of porcine bone marrow mesenchymal stem cells. Researchers can explore the expression of osteogenic markers, observe the differentiation process into the osteogenic lineage, study morphological changes, and assess matrix formation in osteogenic cells. Their versatility makes them essential for advancing bone tissue engineering techniques and supporting regenerative medicine development.