For research use only
| Cat No. | ABC-TC0394 |
| Product Type | Human Melanoma Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Vagina |
| Disease | Melanoma |
| Product Code | HMV-2; HMVII; Human Melanoma Vagina-II |
HMVII Cell Line is a model for studying viral infections and cellular interactions, providing insights into disease mechanisms and therapeutic targets.
HMVII is a human vaginal malignant melanoma cell line derived from the primary tumor of a 65-year-old Japanese female. The cells grow adherently with epithelial-like morphology and produce melanin, defining characteristic HMVII cytological features consistent with melanocytic lineage. Cytogenetic analysis reveals multiple chromosomal abnormalities, reflecting aggressive tumor behavior. HMVII harbors an activating NRAS Q61K/R mutation while retaining wild-type BRAF and functional PTEN, making it a valuable model for investigating RAS/MAPK signaling, melanoma heterogeneity, and resistance mechanisms in non-BRAF-mutant subtypes. In addition, HMVII cells respond to type I interferons (IFN-α/β) by activating the JAK–STAT pathway and inducing interferon-stimulated genes (ISGs), which are commonly examined using established HMVII experimental methods in controlled HMVII laboratory research settings. Owing to these molecular and functional characteristics, HMVII exhibits aggressive HMVII tumor behavior and provides a unique platform for exploring therapeutic strategies in rare BRAF⁻/NRAS⁺ melanomas with challenging clinical features.
| Product Code | HMV-2; HMVII; Human Melanoma Vagina-II |
| Species | Human |
| Cat.No | ABC-TC0394 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Vagina |
| Disease | Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
HMV-II cells are widely used in melanoma studies focusing on NRAS-mutated tumor biology, metastatic mechanisms, and therapeutic responses outside of the BRAF-mutant paradigm. The line serves as an excellent model for examining cell migration, invasion, and resistance mechanisms to MEK and PI3K inhibitors. Its pigmentation-related gene expression also makes it suitable for melanogenesis research, UV response assays, and testing immune checkpoint modulation in vitro.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
