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| Product Code | HMV-2; HMVII; Human Melanoma Vagina-II |
| Species | Human |
| Cat.No | ABC-TC0394 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Vagina |
| Disease | Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
HMVII is a human melanoma cell line that was originally isolated from the vagina of a 65-year-old female patient with malignant melanoma. HMVII exhibits epithelial-like morphology and adherent culture properties. Studies have shown that in HMVII cells with intact IFN signaling, ruxolitinib can suppress the IFN response in melanoma cell lines with functional JAK/STAT signaling, thereby sensitizing melanoma to oncolytic vesicular stomatitis virus.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
The HMVII cell line can be used in cytotoxicity experiments, such as testing sensitivity to OV, herpes simplex virus 1 (HSV1-dICP0), and vesicular stomatitis virus (VSV-Δ51). It is also valuable for identifying biomarkers that predict immunotherapy response and resistance mechanisms. Additionally, these cells can be used to study signaling pathways and screen for optimal drugs or drug combinations to treat vaginal malignant melanoma.
