Human Artherosclerosis Peripheral Blood Mononuclear Cells

Description

Human Atherosclerosis Peripheral Blood Mononuclear Cells (PBMCs) are isolated from patients with clinically confirmed atherosclerotic cardiovascular disease, providing researchers with a critical tool to study the inflammatory mechanisms driving this chronic vascular pathology. These human-derived PBMCs contain immune cell populations (monocytes, T cells, and B cells) that exhibit disease-specific activation patterns, including increased pro-inflammatory monocytes (CD14⁺CD16⁺) and activated T cells (CD4⁺CD28⁻) characteristic of atherosclerotic inflammation. The cells display typical mononuclear morphology with intact surface markers and maintain functional capacity for cytokine production (IL-1β, TNF-α, IFN-γ), reflecting their role in plaque formation and progression. Atherosclerosis PBMCs are particularly valuable for investigating the interplay between lipid metabolism and immune activation in cardiovascular disease. These atherosclerotic PBMCs represent a disease-relevant immune model for dissecting chronic vascular inflammation and evaluating anti-inflammatory or lipid-targeted therapeutic strategies.