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Transfected Stable Cell Lines

Human BCR _ABL (P465S) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR _ABL (P465S) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0051C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The BCR ABL (P465S) BAF3 Cell Line is established by stable lentiviral expression of the BCR-ABL fusion gene with a P465S mutation in the ABL kinase domain. This point mutation alters the activation loop, affecting inhibitor binding. Expression is validated by qRT-PCR.
Target
The BCR-ABL P465S mutation contributes to kinase hyperactivation and resistance to certain TKIs. It plays a critical role in advanced CML progression and relapse. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model is applicable for advanced leukemia research, drug resistance studies, and evaluation of novel kinase inhibitors targeting atypical BCR-ABL mutants.

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