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Human BCR_ABL (F317C) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (F317C) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0211C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human BCR_ABL (F317C) BAF3 Cell Line was generated through stable lentiviral transduction of the BAF3 cell line with the human BCR_ABL gene harboring the F317C mutation. BAF3 cells, which are IL-3-dependent murine pro-B cells, become IL-3-independent upon BCR_ABL expression, offering a sensitive assay system for tyrosine kinase inhibitor screening.
Target
BCR_ABL is a fusion oncogene commonly associated with chronic myeloid leukemia (CML). The F317C mutation confers resistance to certain second-generation ABL kinase inhibitors. This model supports the evaluation of drug sensitivity and resistance mechanisms.
AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line serves as a preclinical platform for drug discovery, resistance profiling, and investigation of alternative therapies for BCR_ABL-mutant leukemias.

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