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Transfected Stable Cell Lines

Human BCR_ABL (F359I) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (F359I) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0221C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

This engineered BAF3 cell line stably expresses the human BCR_ABL gene containing the F359I mutation, achieved through lentiviral integration. The mutation induces IL-3-independent proliferation.
Target
The F359I mutation impacts drug binding and contributes to clinical resistance to imatinib and related compounds. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Appropriate for screening resistance-breaking TKIs and understanding the biochemical basis of mutation-induced drug insensitivity.

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