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Transfected Stable Cell Lines

Human BCR_ABL (F359I) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0221C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human BCR_ABL (F359I) BAF3 Cell Line is designed to explore functional consequences of BCR-ABL mutations in leukemia progression and therapy.

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  • Human BCR_ABL (F359I) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (F359I) BAF3 Cell Line

Description

This engineered BAF3 cell line stably expresses the human BCR_ABL gene containing the F359I mutation, achieved through lentiviral integration. The mutation induces IL-3-independent proliferation.
Target
The F359I mutation impacts drug binding and contributes to clinical resistance to imatinib and related compounds. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0221C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Appropriate for screening resistance-breaking TKIs and understanding the biochemical basis of mutation-induced drug insensitivity.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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