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Transfected Stable Cell Lines

Human BCR_ABL (H396P) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (H396P) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0222C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human BCR_ABL (H396P) BAF3 Cell Line expresses a variant of the BCR_ABL gene with the H396P mutation. Stable integration was achieved via lentiviral delivery in BAF3 cells, allowing IL-3-independent growth.
Target
H396P is a gatekeeper mutation associated with resistance to TKIs. It affects ABL kinase conformation and inhibitor accessibility. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Useful for preclinical drug development and mechanistic studies on kinase inhibitor resistance.

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