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Human BCR_ABL (M244V) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (M244V) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0091C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human BCR_ABL (M244V) BAF3 Cell Line is a murine Ba/F3 cell line modified to express the BCR-ABL fusion gene with a clinically relevant M244V mutation. The stable cell line is created using lentiviral vectors, with gene expression verified by qRT-PCR and cultured under low passage conditions (<P20). Target The BCR-ABL oncogene is the hallmark of chronic myeloid leukemia (CML), encoding a constitutively active tyrosine kinase. The M244V mutation may impact kinase function or inhibitor sensitivity. BCR-ABL drives cellular proliferation through STAT, MAPK, and PI3K signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line is a valuable tool for studying BCR-ABL-related leukemogenesis, assessing drug resistance mechanisms, and developing targeted therapeutics such as tyrosine kinase inhibitors (TKIs).

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