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Transfected Stable Cell Lines

Human BCR_ABL (M244V) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0091C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The human BCR-ABL (M244V) BAF3 Cell Line models tyrosine kinase mutations to support research on leukemia progression and therapeutic resistance.

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  • Human BCR_ABL (M244V) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (M244V) BAF3 Cell Line

Description

Human BCR_ABL (M244V) BAF3 Cell Line is a murine Ba/F3 cell line modified to express the BCR-ABL fusion gene with a clinically relevant M244V mutation. The stable cell line is created using lentiviral vectors, with gene expression verified by qRT-PCR and cultured under low passage conditions (<P20). Target The BCR-ABL oncogene is the hallmark of chronic myeloid leukemia (CML), encoding a constitutively active tyrosine kinase. The M244V mutation may impact kinase function or inhibitor sensitivity. BCR-ABL drives cellular proliferation through STAT, MAPK, and PI3K signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Species

Human
Cat.No

ABC-X0091C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line is a valuable tool for studying BCR-ABL-related leukemogenesis, assessing drug resistance mechanisms, and developing targeted therapeutics such as tyrosine kinase inhibitors (TKIs).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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