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Transfected Stable Cell Lines

Human BCR_ABL (V299L) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0223C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human BCR_ABL (V299L) BAF3 Cell Line aids in analyzing mutation-induced resistance to targeted leukemia treatments in vitro experimental models.

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  • Human BCR_ABL (V299L) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (V299L) BAF3 Cell Line

Description

This BAF3 cell line was modified to stably express the V299L-mutant form of BCR_ABL via lentiviral transduction. The mutation renders the cells independent of IL-3 for proliferation.
Target
The V299L mutation is linked to altered sensitivity to second-generation TKIs and affects the drug-binding region of the kinase domain. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0223C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • A valuable model for evaluating kinase inhibitors and understanding mutation-mediated therapy resistance in CML.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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