Human BCR_ABL (V468F) BAF3 Cell Line

Description

Human BCR_ABL (V468F) BAF3 Overexpression Cell Line is a lentiviral-engineered Ba/F3 cell model stably expressing the V468F mutant form of BCR-ABL. The cells are verified by qRT-PCR and maintained under low passage conditions (<P20). Target The V468F mutation in BCR-ABL affects the kinase domain, altering inhibitor sensitivity and contributing to therapeutic resistance in chronic myeloid leukemia (CML). AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Application

• For research use only
  

• This model supports evaluation of second- and third-generation BCR-ABL inhibitors targeting resistance mutations and facilitates exploration of combination therapy strategies.