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Transfected Stable Cell Lines

Human BCR_ABL (Y253H) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0218C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The human BCR_ABL (Y253H) BAF3 Cell Line enables investigation of mutation-driven treatment resistance in chronic myeloid leukemia research.

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  • Human BCR_ABL (Y253H) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (Y253H) BAF3 Cell Line

Description

This cell line expresses the human BCR_ABL gene harboring the Y253H mutation in the BAF3 cell background. Lentiviral transduction enables stable gene integration and cytokine-independent growth.
Target
The Y253H mutation is located in the ATP-binding loop of ABL and is linked to resistance against first- and second-generation TKIs. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0218C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Serves as a model to study mutation-driven resistance and to evaluate efficacy of third-generation ABL inhibitors.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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