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Transfected Stable Cell Lines

Human BCR_ABL (Y253H) BAF3 Cell Line

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    1

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (Y253H) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0218C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

This cell line expresses the human BCR_ABL gene harboring the Y253H mutation in the BAF3 cell background. Lentiviral transduction enables stable gene integration and cytokine-independent growth.
Target
The Y253H mutation is located in the ATP-binding loop of ABL and is linked to resistance against first- and second-generation TKIs. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Serves as a model to study mutation-driven resistance and to evaluate efficacy of third-generation ABL inhibitors.

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