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Species | Human |
Cat.No | ABC-X0218C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Lymphocytes |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Lymphatic |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | BAF3 |
This cell line expresses the human BCR_ABL gene harboring the Y253H mutation in the BAF3 cell background. Lentiviral transduction enables stable gene integration and cytokine-independent growth.
Target
The Y253H mutation is located in the ATP-binding loop of ABL and is linked to resistance against first- and second-generation TKIs. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only