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Transfected Stable Cell Lines

Human BRAF (G464R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0316C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human BRAF (G464R) BAF3 Cell Line enables exploration of BRAF mutation-induced MAPK pathway activation and its implications for drug development.

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  • Human BRAF (G464R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (G464R) BAF3 Cell Line

Description

Human BRAF (G464R) BAF3 Overexpression Cell Line is developed from murine pro-B Ba/F3 cells to express human BRAF with the G464R mutation through lentiviral vector-mediated stable integration. The edited cells are cultured under low-passage conditions (<P20) and confirmed for gene overexpression via qRT-PCR. Target BRAF encodes a serine/threonine-protein kinase involved in the RAS-RAF-MEK-ERK signaling cascade. The G464R substitution, located in the kinase domain, leads to constitutive activation of downstream signaling, promoting cell proliferation and transformation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Species

Human
Cat.No

ABC-X0316C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This model supports the investigation of BRAF (G464R)-mediated oncogenic signaling and drug resistance mechanisms. It is especially suitable for preclinical screening of RAF or MEK inhibitors in hematologic or solid malignancies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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