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Transfected Stable Cell Lines

Human BRAF (G466A) BAF3 Cell Line

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Species

Human

Cat.No

ABC-X0057C

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Lymphocyte

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO₂

Source Organ

Lymphatic

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

BAF3

Description

Human BRAF (G466A) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. The BRAF (G466A) mutant cell line is created by integrating the human BRAF gene with the G466A mutation into Ba/F3 cells using optimized lentiviral transduction.
Target
BRAF is a serine/threonine kinase functioning within the MAPK pathway. The G466A mutation is located in the kinase domain and results in deregulated kinase activity and ERK pathway hyperactivation. It is associated with non-V600E driven malignancies including melanoma and NSCLC. AcceGen offers precise BRAF mutation models for functional validation and drug discovery. Polyclonal or monoclonal is optional.

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Application

  • For research use only

  • The BRAF (G466A) BAF3 Cell Line enables exploration of non-canonical BRAF-driven oncogenic mechanisms, targeted drug response, and resistance development. It is an ideal system for preclinical screening and personalized medicine research.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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