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Human BRAF (G469A) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (G469A) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0046C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human BRAF (G469A) NIH/3T3 Cell Line is a genetically engineered model derived from murine NIH/3T3 fibroblasts based on customers’ requirement. BRAF (G469A) NIH/3T3 mutant cell line is created by stable integration of the human BRAF gene carrying the G469A mutation into NIH/3T3 cells using our proprietary lentiviral transduction approach.
Target
BRAF is a serine/threonine-protein kinase in the RAS-RAF-MEK-ERK signaling cascade. The G469A mutation, located in the activation segment of the kinase domain, enhances kinase activity and promotes tumorigenesis independent of upstream signals. It has been implicated in lung and colorectal cancers. AcceGen provides precise oncogenic models for pathway elucidation and drug testing. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The BRAF (G469A) NIH/3T3 Cell Line serves as a reliable platform to assess BRAF-dependent transformation, MAPK pathway activation, and resistance to BRAF or MEK inhibitors. It is useful for preclinical studies and high-throughput screening of pathway-targeted therapies.

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