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Human BRAF (K601N) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (K601N) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0035C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human BRAF (K601N) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. BRAF (K601N) BAF3 mutant cell line is generated by stable integration of exogenous human BRAF gene harboring the K601N mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
BRAF is a serine/threonine-protein kinase that functions in the RAS/RAF/MEK/ERK signaling cascade, controlling cell growth and survival. The K601N mutation is a class II BRAF mutation that promotes constitutive dimerization and activation independent of upstream RAS input. This variant is frequently detected in non-V600E cancers and contributes to therapy resistance in BRAF-targeted treatments. AcceGen offers custom-engineered stable overexpression models for a variety of oncogenic mutations. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The BRAF (K601N) BAF3 Cell Line is a valuable tool for elucidating non-V600E BRAF signaling and testing MEK/ERK pathway inhibitors. It supports drug discovery efforts, mechanism-of-action studies, and the exploration of resistance pathways in BRAF-driven malignancies.

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