Human Brain Cortex Pericyte Cells

Description

Human Brain Cortex Pericyte Cells are primary cells isolated from healthy human brain cortex tissue. They are cryopreserved at early passage to retain original traits. The cells exhibit stellate or spindle-shaped morphology and adherent growth in monolayer, maintaining their critical roles in neurovascular unit homeostasis. As key blood-brain barrier pericytes, they are crucial for cerebral microcirculation by maintaining the blood-brain barrier, regulating capillary blood flow, and supporting endothelial cells. Their dysregulation is linked to neurodegenerative diseases like Alzheimer’s and multiple sclerosis. These human cells express pericyte-specific markers including alpha-smooth muscle actin (α-SMA) and platelet-derived growth factor receptor-β (PDGFR-β). While maintaining a normal karyotype, these primary cells demonstrate limited expansion capacity under proper cell-culture conditions. For optimal performance, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.